Grant: Project Grant

There have been no truly new antibiotics antibiotics discovered in more than thirty years. During the same time we have seen an alarming increase in reports of "superbugs" with resistance to existing drugs. Indeed, multidrug resistance in bacteria is due largely to the limited repertoire of drugs that eradicate bacteria and with a narrow range of mechanisms. Recognizing the need for new therapies, we seek new tools to better understand bacterial cell systems. In the work proposed here we hope to break fresh ground in the discovery of new probes of the model microbe Escherichia coli with the hope that this work will lead to novel leads for new antibiotics.