Grant: Operating Grant
Research Institute of the McGill University Health Centre
$371,673.00
Role of NLRP7 in the spectrum of reproductive wastage
EF 2010-11
Résumé
Hydatidiform mole is a human pregnancy with no embryo. The paradoxical nature of this condition has fascinated and puzzled scientists in all civilizations. The common form of hydatidiform moles is not recurrent and affects one in every 1000 pregnancies in western countries, but up to 10 in 1000 pregnancies in the Far East. Hydatidiform mole or molar pregnancy is also a benign tumour of the placenta that may persist after dilatation and curettage evacuation and require chemotherapy or degenerate into a choriocarcinoma, a malignant, aggressive, and metastatic cancer and lead to death in the absence of appropriate management. By studying rare families with moles, our group identified a first gene, NLRP7, for this condition. The goal of the current application is to understand more the role of the new gene and investigate its role in the common form of moles and in other forms of reproductive wastage and prenatal morbidities frequently found in patients with moles.
Programme
Operating Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
210582
Name
Slim Rima
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
Role of NLRP7 in the spectrum of reproductive wastage
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$371,673
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Aneuploidies; Foetal Loss; Genetic Mapping; Inflammation; Maternal Defect; Molar Pregnancies; Positional Cloning; Postzygotic Cleavage Abnormalities; Spontaneous Abortions; Stillbirth
Abstract
Hydatidiform mole is a human pregnancy with no embryo. The paradoxical nature of this condition has fascinated and puzzled scientists in all civilizations. The common form of hydatidiform moles is not recurrent and affects one in every 1000 pregnancies in western countries, but up to 10 in 1000 pregnancies in the Far East. Hydatidiform mole or molar pregnancy is also a benign tumour of the placenta that may persist after dilatation and curettage evacuation and require chemotherapy or degenerate into a choriocarcinoma, a malignant, aggressive, and metastatic cancer and lead to death in the absence of appropriate management. By studying rare families with moles, our group identified a first gene, NLRP7, for this condition. The goal of the current application is to understand more the role of the new gene and investigate its role in the common form of moles and in other forms of reproductive wastage and prenatal morbidities frequently found in patients with moles.
Competitiondate
201009
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Slim, Rima
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $371,673~ $0~
