Grant: Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)
Sunnybrook Research Institute (Toronto, Ontario)
$0.00
Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation (REBALANCE)
EF 2022-23
Résumé
Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer's disease (AD). When combined with ultrasound contrast agents (termed 'microbubbles') that are administered to the blood stream, FUS can temporarily and reversibly permeabilize the blood vessels in the brain. The microbubbles vibrate in response to the ultrasound and enhance the delivery of drugs from the bloodstream to the tissue. However, in addition to enabling the delivery of drugs, this treatment has been observed in animal studies to improve the clearance of harmful waste, such as beta amyloid plaques, from the brain and improve cognitive performance in behavioral tests. In this study we will investigate the mechanism of enhanced clearance. Specifically we will study the effect of Piezo1, which is sensitive to mechanical stimuli, on these treatments in mice.
Programme
Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
467520
Name
O'Reilly Meaghan
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
The Academy of Finland; National Research Fund (Luxembourg); Brain Canada Foundation (Montreal, Québec); The French National Research Agency (France); The Netherlands Organization for Health Research and Development (ZonMw); State Education and Development Agency (Latvia)
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Special Cases
Projecttitle
Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation (REBALANCE)
Programtype2
Operating Grants
Orgnameinp2
Sunnybrook Research Institute (Toronto, Ontario)
Cihramount2
$0
Cihrequipment2
$0
Programname2
Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)
Keyworddelim
Alzheimer'S Disease; Focused Ultrasound; Piezo1
Abstract
Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer's disease (AD). When combined with ultrasound contrast agents (termed 'microbubbles') that are administered to the blood stream, FUS can temporarily and reversibly permeabilize the blood vessels in the brain. The microbubbles vibrate in response to the ultrasound and enhance the delivery of drugs from the bloodstream to the tissue. However, in addition to enabling the delivery of drugs, this treatment has been observed in animal studies to improve the clearance of harmful waste, such as beta amyloid plaques, from the brain and improve cognitive performance in behavioral tests. In this study we will investigate the mechanism of enhanced clearance. Specifically we will study the effect of Piezo1, which is sensitive to mechanical stimuli, on these treatments in mice.
Competitiondate
202206
Approvedterm2
3 yrs 0 mth
Pinamesdelim
O'Reilly, Meaghan
Approvedterm
3 ans 0 mois
