Grant: Operating Grant
University of Calgary
$712,555.00
Antigen presenting cell membrane lipids as immune sensors
EF 2011-12
Résumé
We propose here to study how lipids in the immune cell membrane can sense solid structures like crystals and beads. This is an important topic related to vaccine development, implant research, drug delivery and inflammatory responses to air pollution. Specifically, we will study what type of signaling events follow lipid binding in response to these solid structures and how they impact immune outcomes.
Programme
Operating Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
237789
Name
Shi Yan
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
Antigen presenting cell membrane lipids as immune sensors
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$712,555
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Dendritic Cells; Membrane Lipids; Signalling
Abstract
We propose here to study how lipids in the immune cell membrane can sense solid structures like crystals and beads. This is an important topic related to vaccine development, implant research, drug delivery and inflammatory responses to air pollution. Specifically, we will study what type of signaling events follow lipid binding in response to these solid structures and how they impact immune outcomes.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Shi, Yan
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $712,555~ $0~
