Grant: Project Grant
McGill University
$1,044,225.00
Nerve injury-induced inflammation modulates parvalbumin expression to decrease inhibitory tone in the spinal dorsal horn
EF 2018-19
Résumé
Chronic neuropathic pain is a debilitating disease affecting one in fifteen individuals. It is characterized by mechanical allodynia, where touch stimuli are painful. This is due in part to changes in the circuitry of the dorsal horn. This first relay of sensory information processes peripheral inputs before sending them to projection neurons. During neuropathic pain, this processing is altered and the function of inhibitory neurons is reduced. Our previous work demonstrated that parvalbumin containing neurons play an essential role in protecting against mechanical allodynia. The present proposal will investigate the mechanisms underlying the decrease in activity in parvalbumin neurons.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
389595
Name
Sharif-Naeini Reza
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Nerve injury-induced inflammation modulates parvalbumin expression to decrease inhibitory tone in the spinal dorsal horn
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$1,044,225
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Calcium-Activated Potassium Channel; Dorsal Horn; Frequency Adaptation; Mechanical Allodynia; Nerve Injury; Pain; Parvalbumin; Patch Clamp; Spinal Cord
Abstract
Chronic neuropathic pain is a debilitating disease affecting one in fifteen individuals. It is characterized by mechanical allodynia, where touch stimuli are painful. This is due in part to changes in the circuitry of the dorsal horn. This first relay of sensory information processes peripheral inputs before sending them to projection neurons. During neuropathic pain, this processing is altered and the function of inhibitory neurons is reduced. Our previous work demonstrated that parvalbumin containing neurons play an essential role in protecting against mechanical allodynia. The present proposal will investigate the mechanisms underlying the decrease in activity in parvalbumin neurons.
Competitiondate
201809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sharif-Naeini, Reza
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,044,225~ $0~
