Grant: Operating Grant: Programmatic Grants in Food & Heallth-Basic Biomedical Science
Université Laval
$2,000,000.00
Translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients: from animal models to obese insulin-resistant subjects
EF 2012-13
Résumé
Few Canadians meet the weekly recommendations of fish consumption and thus intakes of not only n-3 PUFA but also of fish proteins and vitamin D are low in the general population and even lower in obese subjects. Moreover, many Canadians, especially obese subjects, have low (<50 nmol/L) or suboptimal (<75 nmol/L) serum concentrations of vitamin D. Low intake of those fish nutrients increase the risk for type 2 diabetes (T2D) and cardiovascular disease (CVD). The overall goal of this programmatic grant application is to investigate the effects and the mechanisms of action of fish peptides and vitamin D, along with fish omega3 fatty acids on cardiometabolic risk factors in animal models of obesity-linked T2D and CVD and in human obese subjects. We plan to use nutrigenomic and metabolomic approaches to study the individual responses to fish peptides and vitamin D interventions and to discover new gene/metabolite networks underlying these effects, and potentially novel biomarkers to predict the risk of T2D and CVD in obese subjects.
Programme
Operating Grant: Programmatic Grants in Food & Heallth-Basic Biomedical Science
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
288805
Name
Marette André
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Operating Grant: Programmatic Grants in Food and Health
Projecttitle
Translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients: from animal models to obese insulin-resistant subjects
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$2,000,000
Cihrequipment2
$0
Programname2
Operating Grant: Programmatic Grants in Food & Heallth-Basic Biomedical Science
Keyworddelim
Animal Models; Cardiovascular Disease; Fish Nutrients; Human Subjects; Insulin Resistance; Metabolomics; Nutrigenomics; Obesity; Type 2 Diabetes; Vitamin D
Abstract
Few Canadians meet the weekly recommendations of fish consumption and thus intakes of not only n-3 PUFA but also of fish proteins and vitamin D are low in the general population and even lower in obese subjects. Moreover, many Canadians, especially obese subjects, have low (<50 nmol/L) or suboptimal (<75 nmol/L) serum concentrations of vitamin D. Low intake of those fish nutrients increase the risk for type 2 diabetes (T2D) and cardiovascular disease (CVD). The overall goal of this programmatic grant application is to investigate the effects and the mechanisms of action of fish peptides and vitamin D, along with fish omega3 fatty acids on cardiometabolic risk factors in animal models of obesity-linked T2D and CVD and in human obese subjects. We plan to use nutrigenomic and metabolomic approaches to study the individual responses to fish peptides and vitamin D interventions and to discover new gene/metabolite networks underlying these effects, and potentially novel biomarkers to predict the risk of T2D and CVD in obese subjects.
Competitiondate
201301
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Marette, André; Ang, Keng-Pee
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $2,000,000~ $0~
