Grant: Project Grant
Research Institute of the McGill University Health Centre
$872,100.00
Molecular analysis of the Rac1/Cdc42 regulator CdGAP in development and breast cancer
EF 2016-17
Résumé
Breast cancer is the second cause of cancer-related deaths amongst women after lung cancer. The availability of a wide range of therapeutic approaches creates a need for the development of individualized medicine leading to more accurate and efficient treatment responses. It is imperative to distinguish high-risk patients who require more aggressive chemotherapies combined to surgery versus low-risk patients who do not need invasive therapies like mastectomy. The proposed project has the very high potential to identify novel biomarkers and to develop targeted novel therapeutic strategies for the treatment of breast cancer metastasis. Therefore, it will be of great help for breast cancer patients and clinicians.
Programme
Project Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
357762
Name
Lamarche-Vane Nathalie
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Molecular analysis of the Rac1/Cdc42 regulator CdGAP in development and breast cancer
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$872,100
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Breast Cancer; Cell Migration; Cytoskeleton; Development; Molecular Mechanisms; Mouse Models; Rho Gtpase Mechanisms; Tgfb Signaling
Abstract
Breast cancer is the second cause of cancer-related deaths amongst women after lung cancer. The availability of a wide range of therapeutic approaches creates a need for the development of individualized medicine leading to more accurate and efficient treatment responses. It is imperative to distinguish high-risk patients who require more aggressive chemotherapies combined to surgery versus low-risk patients who do not need invasive therapies like mastectomy. The proposed project has the very high potential to identify novel biomarkers and to develop targeted novel therapeutic strategies for the treatment of breast cancer metastasis. Therefore, it will be of great help for breast cancer patients and clinicians.
Competitiondate
201610
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Lamarche-Vane, Nathalie
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $872,100~ $0~
