Grant: Operating Grant
McMaster University
$609,934.00
Antidepressant use during pregnancy and the risk of metabolic disturbances in the offspring
EF 2011-12
Résumé
Women of childbearing age appear to be particularly vulnerable to depression around the time of pregnancy. As a result it has been estimated that up to 1 in 5 women take antidepressant medications during pregnancy. Although in adults these drugs can increase the risk of type 2 diabetes, it is unknown whether a woman's antidepressant use during pregnancy increases the risk of diabetes in her children. Therefore the goal of this project is to determine in an animal model whether maternal exposure to a commonly used antidepressant is related to the development of diabetes in the offspring. We will also examine the mechanism(s) by which maternal antidepressant use may lead to metabolic disorders in the exposed children.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
238073
Name
Holloway Alison C
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Clinical Investigation - A: Reproduction, Maternal, Child and Youth Health
Projecttitle
Antidepressant use during pregnancy and the risk of metabolic disturbances in the offspring
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$609,934
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Antidepressants; Beta Cell; Fetal Programming Of Adult Disease; Obesity; Pregnancy; Type 2 Diabetes
Abstract
Women of childbearing age appear to be particularly vulnerable to depression around the time of pregnancy. As a result it has been estimated that up to 1 in 5 women take antidepressant medications during pregnancy. Although in adults these drugs can increase the risk of type 2 diabetes, it is unknown whether a woman's antidepressant use during pregnancy increases the risk of diabetes in her children. Therefore the goal of this project is to determine in an animal model whether maternal exposure to a commonly used antidepressant is related to the development of diabetes in the offspring. We will also examine the mechanism(s) by which maternal antidepressant use may lead to metabolic disorders in the exposed children.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Holloway, Alison C
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $609,934~ $0~
