Grant: Travel Awards - Institute Community Support
Direct Payment
$2,500.00
NK cell receptor-mediated direct fungal recognition and cytotoxicity that is defective in HIV-infected patients but restored using IL-12
EF 2013-14
Résumé
ICS Travel Awards
Persons living with AIDS are at risk of developing devastating fungal infections. The most deadly fungus, Cryptococcus neoformans causes pneumonia and meningitis and kills over 600,000 persons with AIDS per year. We have been working to bypass the immune defect in AIDS patients to combat this dreaded infection. It has been known for many years that a class of white blood cells called natural killer (NK) cells can bind and directly kill fungi. However, the NK cell receptor that is used to recognize the fungus had not been discovered. Moreover, it was not known whether the NK cell receptor might be defective in AIDS patients and explain part of the problem. In the work to be presented at this meeting, we will describe how we screened over 2600 different antibodies to discover the receptor. We also found that expression of the receptor is defective in AIDS patients, but can be restored with a molecule (interleukin 12) that boosts immunity. Once the expression of the receptor was restored, the NK cells from AIDS patients killed Cryptococcus normally.
Programme
Travel Awards - Institute Community Support
Bénéficiaire
Emplacement
Alberta, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
288303
Name
Li Shushun
Region
Alberta
Country
Canada
Orgtype
Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
HIV/AIDS and/or other Sexually Transmitted and Blood-borne Infections (STBBIs).
Projecttitle
NK cell receptor-mediated direct fungal recognition and cytotoxicity that is defective in HIV-infected patients but restored using IL-12
Programtype2
Undefined
Orgnameinp2
Direct Payment
Cihramount2
$2,500
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Cryptococcosis; Hiv Co-Infection; Host Pathogen Response; Ics Travel Awards; Immunodeficiency; Immunotherapy; Innate Immunity; Natural Killer Cells; Nk Fungicidal Receptor; Nk Receptor Mediated Killing
Abstract
ICS Travel Awards
Persons living with AIDS are at risk of developing devastating fungal infections. The most deadly fungus, Cryptococcus neoformans causes pneumonia and meningitis and kills over 600,000 persons with AIDS per year. We have been working to bypass the immune defect in AIDS patients to combat this dreaded infection. It has been known for many years that a class of white blood cells called natural killer (NK) cells can bind and directly kill fungi. However, the NK cell receptor that is used to recognize the fungus had not been discovered. Moreover, it was not known whether the NK cell receptor might be defective in AIDS patients and explain part of the problem. In the work to be presented at this meeting, we will describe how we screened over 2600 different antibodies to discover the receptor. We also found that expression of the receptor is defective in AIDS patients, but can be restored with a molecule (interleukin 12) that boosts immunity. Once the expression of the receptor was restored, the NK cells from AIDS patients killed Cryptococcus normally.
Competitiondate
201305
Approvedterm2
0 yr 3 mths
Pinamesdelim
Li, Shushun
Approvedterm
0 an 3 mois
Cihrcontribution2
HIV/AIDS~ $2,500~ $0~
