Grant: Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Université Laval
$422,731.00
Possible outcomes of Leishmania co-infection on HIV-1 immunopathogenesis, latency and reactivation
EF 2014-15
Résumé
We are proposing to investigate the putative consequence(s) of biological interactions that may occur between the protozoan parasite Leishmania and HIV-1. It is crucial to improve our understanding of the complex interconnections which may occur between both infectious agents because leishmaniasis is now considered as an emerging disease in at least 30 countries worldwide where HIV-1 is frequently prevalent. It is anticipated that the data from the planned studies described herein will contribute also to our overall understanding of the disease's pathogenesis and mechanisms of HIV-1 transmission. A better comprehension regarding the impact of a co-infecting agent such as Leishmania on HV-1 biology is crucial because in countries where antiretroviral drug are not widely available there is also a high incidence of opportunistic and endemic infectious diseases such as leishmaniasis.
Programme
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
328902
Name
Tremblay Michel J
Region
Québec
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis 2
Projecttitle
Possible outcomes of Leishmania co-infection on HIV-1 immunopathogenesis, latency and reactivation
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$422,731
Cihrequipment2
$0
Programname2
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Keyworddelim
B Cells; Cd4+ T Cells; Dendritic Cells; Hiv-1; Il-10; Leishmania; Macrophage; Samhd1; Soluble Factors; Virus Latency
Abstract
We are proposing to investigate the putative consequence(s) of biological interactions that may occur between the protozoan parasite Leishmania and HIV-1. It is crucial to improve our understanding of the complex interconnections which may occur between both infectious agents because leishmaniasis is now considered as an emerging disease in at least 30 countries worldwide where HIV-1 is frequently prevalent. It is anticipated that the data from the planned studies described herein will contribute also to our overall understanding of the disease's pathogenesis and mechanisms of HIV-1 transmission. A better comprehension regarding the impact of a co-infecting agent such as Leishmania on HV-1 biology is crucial because in countries where antiretroviral drug are not widely available there is also a high incidence of opportunistic and endemic infectious diseases such as leishmaniasis.
Competitiondate
201503
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Tremblay, Michel J
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $422,731~ $0~
