Grant: Operating Grant
Université de Montréal
$792,120.00
The Role of Thymoproteasomes in T-Cell Development
EF 2010-11
Résumé
The differentiation of T lymphocytes takes place only in the thymus, largely because the thymus produces a unique protein called the thymoproteasome. The goal of this project is to understand the biochemical and biological roles of the thymoproteasome. As thymic function progressively diminishes with age in all individuals, and decreased thymic capacity causes impaired resistance to infections and cancer, understanding (and enhancing) thymic function could have an important impact on health management in elderly subjects.
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
222875
Name
Perreault Claude
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
The Role of Thymoproteasomes in T-Cell Development
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$792,120
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Fetal Thymic Organ Culture; Flow Cytometry; Ko Mice; Major Histocompatibility Complex; Mass Spectrometry; Proteasome; Proteomics; T-Cell Development; Transcriptome Sequencing
Abstract
The differentiation of T lymphocytes takes place only in the thymus, largely because the thymus produces a unique protein called the thymoproteasome. The goal of this project is to understand the biochemical and biological roles of the thymoproteasome. As thymic function progressively diminishes with age in all individuals, and decreased thymic capacity causes impaired resistance to infections and cancer, understanding (and enhancing) thymic function could have an important impact on health management in elderly subjects.
Competitiondate
201103
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Perreault, Claude
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $792,120~ $0~
