Grant: Collaborative Research and Development Grants
University of Saskatchewan
$141,600.00
Innovative cryopreservation protocol optimization for bovine sperm and embryos.**
EF 2018-19
Résumé
This project seeks to optimize sperm and embryo cryopreservation protocols through novel mathematical modelling and experimental design. For bull sperm, we apply a novel strategy of iterative protocol and media optimization that capitalizes on existing damage and membrane transport models to inform next trial steps in the development of complete cryopreservation protocols. For bovine embryos, we will use mathematically guided real-time feedback control of embryo volumes via CPA concentrations to equilibrate embryos in high CPA concentrations with one of three mathematically optimal approaches: minimal time, minimal CPA toxicity, or minimal embryos volume excursion.
Programme
Collaborative Research and Development Grants
Bénéficiaire
Emplacement
Saskatchewan, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
531082-2018
Name nom
Benson, James
Department département
Biology
Organization id
16
Institution établissement
University of Saskatchewan
Province en
Saskatchewan
Province fr
Saskatchewan
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2018
Competition year année de concours
2018
Award amount
141600
Program id
CRDPJ
Program name en
Collaborative Research and Development Grants
Program name fr
Subventions de recherche et développement coopérative
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
100
Area of application group en
Agriculture and primary food production
Area of application group fr
Agriculture et produits alimentaires primaires
Area of application en
Agriculture and primary food production
Area of application fr
Agriculture et produits alimentaires primaires
Research subject code
5505
Research subject group en
Animal biology
Research subject group fr
Biologie animale
Research subject en
Animal reproduction
Research subject fr
Reproduction animale
Partie
1
Nb partie
1
Application title
Innovative cryopreservation protocol optimization for bovine sperm and embryos.**
Keyword
NSERC
Application summary
This project seeks to optimize sperm and embryo cryopreservation protocols through novel mathematical modelling and experimental design. For bull sperm, we apply a novel strategy of iterative protocol and media optimization that capitalizes on existing damage and membrane transport models to inform next trial steps in the development of complete cryopreservation protocols. For bovine embryos, we will use mathematically guided real-time feedback control of embryo volumes via CPA concentrations to equilibrate embryos in high CPA concentrations with one of three mathematically optimal approaches: minimal time, minimal CPA toxicity, or minimal embryos volume excursion.
