Grant: Operating Grant
Research Institute of the McGill University Health Centre
$374,418.00
Identify a second gene for recurrent molar pregnancies and dissect mechanisms of their formation
EF 2009-10
Résumé
Hydatidiform mole (HM) is a human pregnancy with no embryo. Its description figures in Hippocrates' manual under the name of dropsy of the uterus. Despite its ancient recognition, little is known about its causes and the mechanisms underlying its occurrence. The incidence of molar pregnancies is 1 in every 1000 pregnancies in Canada and western countries, but up to 1 in 100 pregnancies in developing and underdeveloped countries. By studying rare families with recurrent moles, our group identified the first gene, NLRP7, for this condition. Now, patients with recurrent moles are offered genetic testing; half of them have mutations in NLRP7 and are provided with appropriate genetic counselling. The goal of this proposal is to map a second gene for this condition to better understand the aetiologies of moles and offer all patients appropriate testing and reproductive counselling.
Programme
Operating Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
188603
Name
Slim Rima
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
Identify a second gene for recurrent molar pregnancies and dissect mechanisms of their formation
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$374,418
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Aneuploidies; Genetic Mapping; Maternal Defect; Molar Pregnancies; Postional Cloning; Spontaneous Abortions
Abstract
Hydatidiform mole (HM) is a human pregnancy with no embryo. Its description figures in Hippocrates' manual under the name of dropsy of the uterus. Despite its ancient recognition, little is known about its causes and the mechanisms underlying its occurrence. The incidence of molar pregnancies is 1 in every 1000 pregnancies in Canada and western countries, but up to 1 in 100 pregnancies in developing and underdeveloped countries. By studying rare families with recurrent moles, our group identified the first gene, NLRP7, for this condition. Now, patients with recurrent moles are offered genetic testing; half of them have mutations in NLRP7 and are provided with appropriate genetic counselling. The goal of this proposal is to map a second gene for this condition to better understand the aetiologies of moles and offer all patients appropriate testing and reproductive counselling.
Competitiondate
200909
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Slim, Rima
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $374,418~ $0~
