Grant: Project Grant
Queen's University (Kingston, Ontario)
$1,071,000.00
Elucidating the role extracellular vesicles play in leukaemogenesis
EF 2020-21
Résumé
Chronic myeloid leukaemia (CML) is a blood cancer, which is fatal if left untreated. Specialised tumour cells called cancer stem cells (CSCs) start and maintain leukaemia. Our group will investigate the processes behind how CML slowly develops, and understand how CSCs communicate with other cells using extracellular vesicles (EVs). EVs are lipid nanoparticles that contain bioactive cargo, that transmit/receive signals or important cellular messages. We will investigate if EVs are important in CML, and if EVs help or hinder in the development of leukaemia. Importantly, we will also investigate if EVs can be used as predictors of CML, thus giving tools for doctors to detect leukaemia as early as possible, so people can live longer and healthier lives.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
433280
Name
Abraham Sheela A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics 2
Projecttitle
Elucidating the role extracellular vesicles play in leukaemogenesis
Programtype2
Operating Grants
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$1,071,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Chronic Myeloid Leukaemia; Clonal Haematopoiesis; Extracellular Vesicles; Haematopoietic Stem Cells; Leukaemia
Abstract
Chronic myeloid leukaemia (CML) is a blood cancer, which is fatal if left untreated. Specialised tumour cells called cancer stem cells (CSCs) start and maintain leukaemia. Our group will investigate the processes behind how CML slowly develops, and understand how CSCs communicate with other cells using extracellular vesicles (EVs). EVs are lipid nanoparticles that contain bioactive cargo, that transmit/receive signals or important cellular messages. We will investigate if EVs are important in CML, and if EVs help or hinder in the development of leukaemia. Importantly, we will also investigate if EVs can be used as predictors of CML, thus giving tools for doctors to detect leukaemia as early as possible, so people can live longer and healthier lives.
Competitiondate
202010
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Abraham, Sheela A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,071,000~ $0~
