Grant: Operating Grant

Pulmonary hypertension is a disease of the lung blood vessels characterized by a sustained proliferation of the cells composing the lung blood vessel wall. This proliferation will decrease blood perfusion and thus blood oxygenation. Despite new therapeutic this disease remain lethal with 30% of mortality within 3 years after diagnostic. We propose to study the role of miR-204 in the proliferation of the cell within pulmonary vessels. Preliminary evidence suggest that the downregulation of miR204 is implicated in the cell proliferation and thus could be of a great therapeutic interest.