Grant: Project Grant

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people and placing a significant burden on healthcare. Research suggests that early intervention before memory loss could be the key to slowing disease progression. Our study focuses on one of the earliest affected brain regions, the dorsal raphe nucleus (DRN) which contains serotonin cells. These cells play a crucial role in emotional and social function, which are impaired early in disease course. We have developed a mouse model that mimics these changes observed in the initial stages of AD, including abnormal buildup of a protein called tau in DRN serotonin neurons and the appearance of behavioural impairments. Our research will explore how tau disrupts function of these cells and the regions they connect with, resulting in the early symptoms of AD. Using cutting-edge imaging, molecular and behavioural techniques in our mouse model, we aim to uncover these changes and test potential treatments to prevent disease progression. By identifying the early changes that disrupt brain function and testing ways to counteract them, our work could help develop new treatments and improve the quality of life for those at risk.