Grant: Operating Grant
University of Toronto
$671,970.00
Maintaining Normal Function of the Periodontal Ligament in Oral Health
EF 2010-11
Résumé
The periodontal ligament is a highly specialized joint that attaches the teeth to the jaw bone and distributes chewing forces to the jaws. The periodontal ligament is essential for mastication and the health of the oral cavity. Specialized cells in the periodontal ligament (fibroblasts) maintain the proteins that attach the tooth roots to the jaw bone. Currently, the mechanisms by which cells in the periodontal ligament maintain their normal structure and function in spite of the high forces that are delivered to them as a result of chewing, are not understood. The purpose of this application is to determine how cells in the periodontal ligament respond to applied mechanical forces and maintain their ability to synthesize and remodel the attachment proteins that anchor the teeth to the jaw bone.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
209864
Name
McCulloch Christopher A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage
Projecttitle
Maintaining Normal Function of the Periodontal Ligament in Oral Health
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$671,970
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Calcium Signaling; Cell Adhesion; Cytoskeletal Proteins; Integrins; Mechanical Forces; Periodontium
Abstract
The periodontal ligament is a highly specialized joint that attaches the teeth to the jaw bone and distributes chewing forces to the jaws. The periodontal ligament is essential for mastication and the health of the oral cavity. Specialized cells in the periodontal ligament (fibroblasts) maintain the proteins that attach the tooth roots to the jaw bone. Currently, the mechanisms by which cells in the periodontal ligament maintain their normal structure and function in spite of the high forces that are delivered to them as a result of chewing, are not understood. The purpose of this application is to determine how cells in the periodontal ligament respond to applied mechanical forces and maintain their ability to synthesize and remodel the attachment proteins that anchor the teeth to the jaw bone.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
McCulloch, Christopher A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $671,970~ $0~
