Grant: Project Grant
University of British Columbia
$764,500.00
Innate Lymphoid cells and RAR-related orphan receptor alpha (RORa) as therapeutic targets for gastrointestinal fibrosis and Crohn's disease.
EF 2015-16
Résumé
Crohn's Disease is one of two types of inflammatory bowel disease and is characterized by the formation of tissue occlusions (fibrotic strictures) that prevent normal flow of gut contents, result in severe pain and require surgical intervention. Surprisingly little is know about what causes this aspect of Crohn's Disease. We have identified a DNA binding protein that, when inactivated, protects animals from developing the major hallmarks of Crohn's Disease. The goal of this application will be to further reveal how this gene causes Crohn's Disease and to develop a drug that blocks its action as a therapy.
Programme
Project Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
342329
Name
McNagny Kelly M
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Innate Lymphoid cells and RAR-related orphan receptor alpha (RORa) as therapeutic targets for gastrointestinal fibrosis and Crohn's disease.
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$764,500
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bone Marrow Transplantation; Cytokines; Fibrosis; Gastrointestinal; Gene Targeting; Inflammation; Innate Lymphoid Cells; Transcription Factors
Abstract
Crohn's Disease is one of two types of inflammatory bowel disease and is characterized by the formation of tissue occlusions (fibrotic strictures) that prevent normal flow of gut contents, result in severe pain and require surgical intervention. Surprisingly little is know about what causes this aspect of Crohn's Disease. We have identified a DNA binding protein that, when inactivated, protects animals from developing the major hallmarks of Crohn's Disease. The goal of this application will be to further reveal how this gene causes Crohn's Disease and to develop a drug that blocks its action as a therapy.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
McNagny, Kelly M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $764,500~ $0~
