Grant: Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

For the HIV virus to replicate and produce new infectious viral particles, it must use the activity of a number of proteins, including host and viral proteins. One centrally important viral protein is called Tat that functions by increasing the production of viral genes. We have discovered that a newly defined protein discovered in our lab, has the capacity to block the effects of the Tat protein. Our research proposal aims at the precise molecular understanding of how TOE1 is able to accomplish this blocking effect. Our guiding aim is to assist the development of new and effective treatment strategies capable of offering relief to HIV infected AIDS patients.