Grant: Project Grant
Université Laval
$696,150.00
Human herpesvirus 6 and chromosomal integration
EF 2017-18
Résumé
Human herpesvirus 6 is unique by its ability to insert its genetic material (DNA) into the chromosome of the cells it infects. Our laboratory is interested in studying how HHV-6 manages to integrate its DNA into chromosomes and how it can remove itself from the chromosome and initiate a new infection. In addition, we are interested in the impact of HHV-6 integration on the biology of the cell. Our results indicate that compared to control cells, those with HHV-6 integration have reduced ability grow and multiply. How this might come about will be investigated.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
370394
Name
Flamand Louis
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis 2
Projecttitle
Human herpesvirus 6 and chromosomal integration
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$696,150
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Human Herpesvirus 6; Inherited Chromosomally-Integrated Hhv-6; Sheltherin Complex; Telomere; Virus
Abstract
Human herpesvirus 6 is unique by its ability to insert its genetic material (DNA) into the chromosome of the cells it infects. Our laboratory is interested in studying how HHV-6 manages to integrate its DNA into chromosomes and how it can remove itself from the chromosome and initiate a new infection. In addition, we are interested in the impact of HHV-6 integration on the biology of the cell. Our results indicate that compared to control cells, those with HHV-6 integration have reduced ability grow and multiply. How this might come about will be investigated.
Competitiondate
201709
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Flamand, Louis
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $696,150~ $0~
