Grant: Cat. Gr.: STBBI Res.: Beyond HIV/AIDS/Hep. C- STBBI other than HIV/hep. C (gen.)
University of Manitoba
$100,000.00
Immunopathology of papillomavirus:bacterial co-infections in the female genital tract
EF 2023-24
Résumé
Human papillomavirus is one of the most common sexually transmitted disease worldwide and causes approximately 5% of all human cancers. Most cases of cervical cancer (>96%) and mouth cancer (70%) are caused by HPV infections. While there are treatment options for cervical cancer including surgery, radiation or chemoradiation, there is still limited options for treatment for advanced stages of disease. There is also no cure for the millions of individuals already infected with HPV. HPV vaccines are successful, but uptake by high risk individuals worldwide continue to lag. In this study, we will investigate why some women are more prone to HPV infection by studying the biological drivers that leads to cervical cancer. The goal is to uncover information that will separate low and high risk HPV associated cervical cancer, and understand how vaginal baceterial communities contribute to HPV infection and cancer development.
Programme
Cat. Gr.: STBBI Res.: Beyond HIV/AIDS/Hep. C- STBBI other than HIV/hep. C (gen.)
Bénéficiaire
Emplacement
Manitoba, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
488760
Name
Murooka Thomas T
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
STBBI Research in Canada: Beyond HIV/AIDS and Hepatitis C (Catalyst)
Projecttitle
Immunopathology of papillomavirus:bacterial co-infections in the female genital tract
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Cat. Gr.: STBBI Res.: Beyond HIV/AIDS/Hep. C- STBBI other than HIV/hep. C (gen.)
Keyworddelim
Cancer Formation; Mouse Model; Mucosal Immunology; Multiplex Tissue Imaging; Neutrophils; Papillomavirus; Vaginal Microbiome; Viral Infection
Abstract
Human papillomavirus is one of the most common sexually transmitted disease worldwide and causes approximately 5% of all human cancers. Most cases of cervical cancer (>96%) and mouth cancer (70%) are caused by HPV infections. While there are treatment options for cervical cancer including surgery, radiation or chemoradiation, there is still limited options for treatment for advanced stages of disease. There is also no cure for the millions of individuals already infected with HPV. HPV vaccines are successful, but uptake by high risk individuals worldwide continue to lag. In this study, we will investigate why some women are more prone to HPV infection by studying the biological drivers that leads to cervical cancer. The goal is to uncover information that will separate low and high risk HPV associated cervical cancer, and understand how vaginal baceterial communities contribute to HPV infection and cancer development.
Competitiondate
202305
Approvedterm2
1 yr 0 mth
Pinamesdelim
Murooka, Thomas T
Approvedterm
1 an 0 mois
Cihrcontribution2
MI #3~ $100,000~ $0~
