Grant: Operating Grant
University of Alberta
$398,616.00
Absorption of ganglioside reduces proinflammatory signaling in the intestine
EF 2010-11
Résumé
Evidence supports the use of gangliosides to improve aspects of IBD. Gangliosides are dietary fats found in milk and are important constituents of the intestinal surface. We propose that ganglioside in the diet can replace ganglioside that is degraded in the gut of IBD patients to restore proper structure and function to the diseased intestine, resulting in disease remission. IBD is a lifelong struggle for patients. Insight into new non-invasive, diet-based treatment strategies would allow patients to live productive, healthy and happy lives.
Programme
Operating Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
210704
Name
Clandinin Michael T
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Nutrition, Food & Health
Projecttitle
Absorption of ganglioside reduces proinflammatory signaling in the intestine
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$398,616
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Enterocyte; Gangliosides; Human; Inflammation; Metabolism; Nutrition; Tnfa
Abstract
Evidence supports the use of gangliosides to improve aspects of IBD. Gangliosides are dietary fats found in milk and are important constituents of the intestinal surface. We propose that ganglioside in the diet can replace ganglioside that is degraded in the gut of IBD patients to restore proper structure and function to the diseased intestine, resulting in disease remission. IBD is a lifelong struggle for patients. Insight into new non-invasive, diet-based treatment strategies would allow patients to live productive, healthy and happy lives.
Competitiondate
201009
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Clandinin, Michael T
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $398,616~ $0~