Grant: Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador

Impairments in one-carbon metabolism may result either from some vitamin deficiencies (Folate or Vitamin B12) or from genetic causes. These result in increased incidence of neural tube defects and are also associated with cognitive impairment in the elderly, as well as cardiovascular disease. We have found that formate (found in ant stings as formic acid) accumulates in the blood in these situations and may serve as an important indicator of ill health. It may be more than an indicator, it may play a causal role. We will investigate these questions in experimental animals and blood samples from large human populations.