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Grant: Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology

University of Alberta|Université de l'Alberta

$277,805.00

Simulated Microgravity in Understanding Knee Osteoarthritis

EF 2021-22 · 2022-03-17

Résumé
There is little attention on the potential impact of spaceflight associated low gravity (microgravity) on joint health. Osteoarthritis is the most common joint disease, and it primarily affects the mechanical loading bearing structures of the joint. Its negative effect on patients' quality of life is enormous. Over 10% of the Canadian population suffer from osteoarthritis, and the most common joint affected is the knee. Knee osteoarthritis is prevalent in females. The reason for the high incidence of knee osteoarthritis in females is not fully understood. This project will explore the use of simulated microgravity to understand the basis of the prevalence of knee osteoarthritis in females. The findings of this project have the potential to discover novel drug targets for treating knee osteoarthritis to alleviate the burden of the disease in Canada and globally. Additionally, the project can potentially advance the use of simulated microgravity to study other joint disorders.
Programme
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Emplacement
Edmonton|Edmonton, Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
Proactive Disclosure - Grants and Contributions

Tel que publié

Additional Information
The amount allocated covers more than one fiscal year.
Additional Information (French)
La somme allouée couvre plus d'un exercice financier.
Agreement End Date
2025-03-01
Agreement Number
21FAALBA04
Agreement Start Date
2022-03-17
Agreement Title
Simulated Microgravity in Understanding Knee Osteoarthritis
Agreement Title (French)
Recours à la microgravité simulée pour comprendre l’arthrose du genou
Agreement Type
Grant
Agreement Value
$277,805.00
Amendment Number
0
Description
There is little attention on the potential impact of spaceflight associated low gravity (microgravity) on joint health. Osteoarthritis is the most common joint disease, and it primarily affects the mechanical loading bearing structures of the joint. Its negative effect on patients' quality of life is enormous. Over 10% of the Canadian population suffer from osteoarthritis, and the most common joint affected is the knee. Knee osteoarthritis is prevalent in females. The reason for the high incidence of knee osteoarthritis in females is not fully understood. This project will explore the use of simulated microgravity to understand the basis of the prevalence of knee osteoarthritis in females. The findings of this project have the potential to discover novel drug targets for treating knee osteoarthritis to alleviate the burden of the disease in Canada and globally. Additionally, the project can potentially advance the use of simulated microgravity to study other joint disorders.
Description (French)
Peu d’attention a été accordée aux répercussions potentielles de la faible gravité (microgravité) associées aux vols spatiaux sur la santé des articulations. L’arthrose, qui est la maladie articulaire la plus courante, affecte principalement les structures mécaniques porteuses des articulations. Ses effets négatifs sur la qualité de vie des patients sont énormes. Plus de 10 % de la population canadienne souffre d’arthrose, et l’articulation la plus fréquemment touchée est le genou. L’arthrose du genou est plus fréquente chez les femmes, pour des raisons encore mal comprises aujourd’hui. Ce projet étudiera l’utilisation de la microgravité simulée pour comprendre les raisons fondamentales de la prévalence de l’arthrose du genou chez les femmes. Les résultats de ce projet pourraient mener à la découverte de nouvelles cibles pharmacologiques pour le traitement de l’arthrose du genou afin d’alléger le fardeau de la maladie au Canada et dans le monde. De plus, le projet pourrait faire progresser l’utilisation de la microgravité simulée pour étudier d’autres troubles articulaires.
Expected Results
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Expected Results (French)
Le volet Recherche du programme offre aux organisations une aide financière qui leur permettra de mener leurs activités de recherche et développement spatiales dans des secteurs prioritaires. Ce volet appuiera le développement des connaissances et l’innovation dans les domaines ciblés de manière à soutenir et à accroître la capacité du Canada d’utiliser l’espace pour répondre aux besoins et aux priorités du pays dans le futur.
Organization Code
csa-asc
Organization
Canadian Space Agency | Agence spatiale canadienne
Program Name
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Name (French)
Programme global de subventions et contributions à l'appui de la recherche, de la sensibilisation et de l'éducation en sciences et technologies spatiales
Program Purpose
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities. The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.
Program Purpose (French)
Ce programme appuie le développement des connaissances et l'innovation dans des domaines prioritaires de l'ASC et accroît la sensibilisation et la participation des Canadiens aux disciplines et aux activités liées à l'espace. Le volet Recherche vise à soutenir le développement des sciences et des technologies, à favoriser le développement continu d'une masse critique de chercheurs et de personnes hautement qualifiées au Canada, et à appuyer la collecte d'information, la recherche et les études relatives à l'espace en tenant compte des priorités de l'ASC.
Recipient City
Edmonton|Edmonton
Recipient Country
CA
Recipient Legal Name
University of Alberta|Université de l'Alberta
Recipient Postal Code
T6G 2E1
Recipient Province or Territory
AB
Recipient Type
S
Reference Number
003-2021-2022-Q4-00026