Grant: Travel Awards - Institute Community Support
Direct Payment
$1,400.00
Down-regulation of dysferlin and myoferlin in human airway epithelium: differential effects on cell morphology and adhesion.
EF 2011-12
Résumé
Normal airway epithelial homeostasis and integrity are not only crucial for protecting airway mucosa from injury caused by inhaled environmental antigens, but also for repairing, regenerating and remodeling after injury in respiratory diseases. In our study, we showed that myoferlin, a membrane repair protein, regulates the tight junction formation within human airway epithelium. This finding has huge implication to advance the development of therapeutic treatments to reconstitute normal epithelium in patients with respiratory diseases.
Programme
Travel Awards - Institute Community Support
Bénéficiaire
Emplacement
British Columbia, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
253473
Name
Leung Suk Kei
Region
British Columbia
Country
Canada
Orgtype
Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Institute of Circulatory and Respiratory Health
Projecttitle
Down-regulation of dysferlin and myoferlin in human airway epithelium: differential effects on cell morphology and adhesion.
Programtype2
Undefined
Orgnameinp2
Direct Payment
Cihramount2
$1,400
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Cell Adhesion; Dysferlin; Human Airway Epithelium; Myoferlin; Tight Junction; Zonular Occludens-1
Abstract
Normal airway epithelial homeostasis and integrity are not only crucial for protecting airway mucosa from injury caused by inhaled environmental antigens, but also for repairing, regenerating and remodeling after injury in respiratory diseases. In our study, we showed that myoferlin, a membrane repair protein, regulates the tight junction formation within human airway epithelium. This finding has huge implication to advance the development of therapeutic treatments to reconstitute normal epithelium in patients with respiratory diseases.
Competitiondate
201201
Approvedterm2
0 yr 1 mth
Pinamesdelim
Leung, Suk Kei
Approvedterm
0 an 1 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $1,400~ $0~
