Grant: Project Grant
University of Alberta
$431,944.00
Rac1 phosphorylation: A novel mechanism to regulate Rac1 activity and function
EF 2015-16
Résumé
Rho GTPases mediate a plethora of cellular effects including regulation of cell size, proliferation, apoptosis/survival, cell adhesion, cell motility and membrane trafficking. Accumulating evidence has implicated Rho GTPases in many aspects of cancer development, and deregulated Rho GTPases have been discovered in many human tumors, including colon, breast, lung, myeloma, and head and neck squamous-cell carcinorma. Our proposed research is to understand how the activity of Rac1, a member of Rho GTPases, is regulated by a specific and previously unappreciated mechanism, phosphorylation. We will also determine how this regulation affects the function of Rac1 in various cellular events especially cancer cell invasion.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
342642
Name
Wang Zhixiang
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Rac1 phosphorylation: A novel mechanism to regulate Rac1 activity and function
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$431,944
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Breast Cancer; Cell Signaling; Egf; Nuclear Speckle; Phosphorylation; Rac1; Receptor Tyrosine Kinases; Rho Gtpases; Rna Splicing; Subcellular Localization
Abstract
Rho GTPases mediate a plethora of cellular effects including regulation of cell size, proliferation, apoptosis/survival, cell adhesion, cell motility and membrane trafficking. Accumulating evidence has implicated Rho GTPases in many aspects of cancer development, and deregulated Rho GTPases have been discovered in many human tumors, including colon, breast, lung, myeloma, and head and neck squamous-cell carcinorma. Our proposed research is to understand how the activity of Rac1, a member of Rho GTPases, is regulated by a specific and previously unappreciated mechanism, phosphorylation. We will also determine how this regulation affects the function of Rac1 in various cellular events especially cancer cell invasion.
Competitiondate
201603
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Wang, Zhixiang
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $431,944~ $0~
