Grant: Operating Grant: Epigenetics Clinical Translation

About 5 to 10% of Canadians live with chronic pain in their mouth, jaws and face (called orofacial pain) caused by temporomandibular disorder (or TMD, meaning issues with your jaw or the muscles that control it). TMD's cause is unknown and there are no specific molecular markers for TMD to help diagnose, predict or treat it. While TMD has some inherited genetic components that are passed on through families, how are genes work can be modulated by environmental factors such as exposure to stress, inflammation, diet, and medication. One way that environmental factors alter how our genes work is by adding 'marks' to the DNA through a process called methylation. We will study blood and tissue samples provided by healthy people and people with TMD, as well as people with other chronic pain conditions. All samples will be examined for genome-wide methylation patterns. These studies will allow us to identify how methylation patterns affect TMD, who will get TMD and who will not, and whose TMD will persist over time. In addition, by comparing to samples from other types of chronic pain, we will identify methylation patterns in people that are common to TMD and other chronic pain conditions. Ultimately this will help us understand more about how the environment affects a person's genetics in terms of their risk of TMD and how better to predict, diagnose, and ultimately treat or prevent painful TMD.