Grant: Operating Grant

In my laboratory, we are exploring the molecular mechanisms that regulate the structure and function of the specialized endothelial cells lining our blood vessels. Endothelial cells depend on the underlying actin cytoskeleton for cellular shape and movement, key processes in angiogenesis that occur during normal development and wound healing, as well as in pathological states such as inflammation and tumour growth. We are investigating an actin-associated protein which we hypothesize is central to these processes. Increasing our understanding of endothelial cell biology and blood vessel growth may reveal novel molecular targets that can be used for the development of therapeutic strategies against cardiovascular diseases and cancer. In turn, these initiatives will aid in reducing the enormous burden of vascular diseases in Canada.