Grant: Operating Grant

When you think about molecules like adrenaline and how they interact with the cell- you usually think of a cell surface receptor and events controlled from that location. The classical view of cellular signalling through G protein-coupled receptors is that they signal exclusively at the cell surface. However, many recent studies have demonstrated that not all of these receptors are transported to the cell surface and may in fact be targetted to internal cellular structures such as the nucleus, ER and Golgi apparatus. In these sites, they regulate a number of cellular events in a distinct manner from those they regulate at the cell surface. We are interested in determining how these signalling systems are differentially targetted and how they may play novel roles in cellular metabolism in health and disease.