Grant: Operating Grant

The electroencephalogram (EEG) has been considered until recently to contain signals with frequencies up to 100Hz. Recent work has demonstrated the presence of signals of very low amplitude and high frequency (100 to 500Hz), which may be of importance in epilepsy. The purpose of this application is to establish an efficient methodology to record and quantify this activity, and to assess its importance in the localization of the brain regions generating epileptic discharges, to improve the chances that the surgical treatment of epilepsy is successful. It is also expected that these high frequency activities will help in understanding how abnormal tissue can generate seizures.