Grant: Travel Awards - Institute Community Support

Angiotensin receptors are present within the body, more abundantly in the heart, kidney, lung, brain and mediate key physiological responses. At the cellular level, these receptors are present on the surface and intracellularly. The specific biological responses and mechanisms of intracellular receptors are less known because of difficulty in selectively targeting the intracrine system. Chemical synthesis of peptides offers the possibility to incorporate residues, like a photo-cleavable moiety, into amino acid sequences. In the present study we present a new caged analog [Tyr(DMNB)4]Ang-II that provides a temporally and spatially controlled release of Ang-II upon UV-irradiation and provides a versatile tool for studying the function and molecular pharmacology of intracrine Ang-II signalling.