Grant: Operating Grant

The Met receptor is dysregulated in many human cancers and Gab proteins are elevated in many human cancers. Hence, it is critical to understand at the mechanistic level how Met and the Gab proteins contribute to and mediate loss of epithelial organization and invasive responses, which contribute to tumor progression and metastases when dysregulated in human cancers. These experiments will identify key and possibly unknown genes and proteins that regulate tumor progression and invasion. Since signalling networks and receptors, such as Met, are potentially suitable sites for drug intervention, the identification of proteins involved in loss of epithelial polarity and invasion will facilitate the rational design of compounds to interfere with these signaling networks in cancer cells.