Grant: Operating Grant

Endocannabinoids (i.e. cannabinoids synthesized by the human body) play an important role in a variety of neurobiological functions, including memory, nociception, and synapse formation. They are also present in the human retina. However, their role in vision remains unknown. In this proposal, we will investigate the functional impact of cannabinoids on the visual properties of neurons comprising the retina and the visual brain. State-of-the-art complementary techniques will be used such as optical brain imaging and multiple recording of neurons. This project will help us understanding the mechanisms by which endocannabinoids can modify visual perception. It will also increase our understanding on the contribution of endocannabinoids in the visual deficits observed in pathologies in which a dysfunction of the endocannabinoids system has been demonstrated (such as Huntington's and Alzheimer's diseases).