Grant: Team Grant - HIV/AIDS Comorbidities Prevention and Healthy Living
Centre hospitalier de l'Université de Montréal (CHUM)
$2,476,710.00
Discovering pathways to successful aging in HIV infection
EF 2017-18
Résumé
HIV infection has been associated to accelerated aging, in particular with premature cardiovascular disease and increased rates of frailty.
Our team has established a large cohort, actively follwoing 850 people living with HIV and 200 controls accross 11 study sites in Canada. We wish to use this cohort to answer new clinical questions about aging with HIV.
Specifically, we wish to measure frailty, and develop novel non-invasive methods to evaluate the health of the cardiovascular system using radiology and nuclear medicine procedures. Then, we want to elucidate what are the biological pathways that cause premature cardiovascular disease and frailty in people living with HIV.
Ultimately, we hope to discover novel treatment targets to prevent and reverse the adverse effects of aging with HIV infection.
Programme
Team Grant - HIV/AIDS Comorbidities Prevention and Healthy Living
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
379406
Name
Durand Madeleine
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
HIV/AIDS Comorbidities Prevention and Healthy Living (full application)
Projecttitle
Discovering pathways to successful aging in HIV infection
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$2,476,710
Cihrequipment2
$0
Programname2
Team Grant - HIV/AIDS Comorbidities Prevention and Healthy Living
Keyworddelim
Aging; Cardiovascular; Cardiovascular Imaging; Frailty; Hiv; Hiv Reservoirs; Immune Activation; Sex Ang Gender
Abstract
HIV infection has been associated to accelerated aging, in particular with premature cardiovascular disease and increased rates of frailty.
Our team has established a large cohort, actively follwoing 850 people living with HIV and 200 controls accross 11 study sites in Canada. We wish to use this cohort to answer new clinical questions about aging with HIV.
Specifically, we wish to measure frailty, and develop novel non-invasive methods to evaluate the health of the cardiovascular system using radiology and nuclear medicine procedures. Then, we want to elucidate what are the biological pathways that cause premature cardiovascular disease and frailty in people living with HIV.
Ultimately, we hope to discover novel treatment targets to prevent and reverse the adverse effects of aging with HIV infection.
Competitiondate
201801
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Durand, Madeleine; Margolese, Shari L; Bernard, Nicole F; Chartrand-Lefebvre, Carl; Chomont, Nicolas; Jenabian, Mohammad-Ali; Mansour, Samer; Tremblay, Cécile L; Tsoukas, Christos M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $2,476,710~ $0~
