Grant: Project Grant

At least two types of inflammation exist: type 1 inflammation is generally associated with controlling infections or clearing debris from damage, while type 2 inflammation is active in allergy but also associated with damage repair. Whether someone is more prone to one or the other type of response can influence how they react to damage. Here we propose to study the mechanisms that makes the resting inflammatory environment biased towards one type of response, and how modulating it affects the response to tissue damage. Understanding these mechanisms may reveal strategies to improve the outcome of a wide range of afflictions.