Grant: Catalyst Grant: NWHRI: Innovation Fund - Biomedical Discovery Grants

Postmenopausal syndrome, resulting from estrogen deprivation, encompasses symptoms that significantly impact women's quality of life and can give rise to serious health complications, including osteoporosis, metabolic syndrome, and cardiovascular diseases. Although estrogen replacement therapy is employed to manage menopause-associated disorders, its utility is limited due to notable side effects. Our research, conducted with mice, has revealed that estrogen deprivation triggers the accumulation of senescent cells in various organs. These senescent cells can impede normal tissue regeneration and perpetually release pro-inflammatory mediators that contribute to tissue damage. Consequently, we anticipate that targeting and eliminating senescent cells could present a novel approach to prevent and treat postmenopausal syndrome. To enhance the significance and breadth of our investigation, we aim to demonstrate that estrogen deprivation induces senescent cell accumulation in humans as well. To tackle this pivotal question, we have assembled a dedicated research team with substantial expertise in women's health. Over the course of numerous years, we have carefully collected unique samples from women of varying ages. These invaluable samples, combined with cutting-edge technological advancements, position us to explore new diagnostic and therapeutic possibilities in this field. Through our concerted efforts, we strive to expand knowledge, improve diagnostics, and develop innovative treatments to address the challenges faced by women experiencing postmenopausal syndrome.