Grant: Project Grant
University of Alberta
$852,975.00
Using advanced imaging techniques to demonstrate hippocampal subfield pathology and predict surgical outcome in temporal lobe epilepsy
EF 2019-20
Résumé
One third of patients with epilepsy are unable to control their seizures with medication. For these patients, surgery can cure their epilepsy if the area in the brain that the seizures start from can be identified and removed. However, among patients who undergo this brain surgery, seizures recur in 50% of patients. Given this poor success rate, better tools are needed to select patients for surgery and predict their outcomes. We have developed a new MRI method that provides far superior resolution (8x) compared to standard MRI, and shows promise in uncovering important information about brain structure that may predict seizure outcomes in these patients. The ultimate goal of this proposal is to develop new advanced MRI techniques that will allow doctors and patients to make more informed decisions about whether brain surgery is the right option for them and if it is likely to cure their epilepsy.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
408933
Name
Gross Donald W
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Clinical
Prcname2
Behavioural Sciences - B-2
Projecttitle
Using advanced imaging techniques to demonstrate hippocampal subfield pathology and predict surgical outcome in temporal lobe epilepsy
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$852,975
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Diffusion Tensor Imaging; Epilepsy Surgery; Hippocampal Sclerosis; Hippocampal Subfields; Memory; Surgical Outcome; Temporal Lobe Epilepsy
Abstract
One third of patients with epilepsy are unable to control their seizures with medication. For these patients, surgery can cure their epilepsy if the area in the brain that the seizures start from can be identified and removed. However, among patients who undergo this brain surgery, seizures recur in 50% of patients. Given this poor success rate, better tools are needed to select patients for surgery and predict their outcomes. We have developed a new MRI method that provides far superior resolution (8x) compared to standard MRI, and shows promise in uncovering important information about brain structure that may predict seizure outcomes in these patients. The ultimate goal of this proposal is to develop new advanced MRI techniques that will allow doctors and patients to make more informed decisions about whether brain surgery is the right option for them and if it is likely to cure their epilepsy.
Competitiondate
201909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Gross, Donald W
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $852,975~ $0~
