Grant: Operating Grant
Ottawa Hospital Research Institute
$46,243.00
GENErVTE: Gene Gene Interactions and Recurrent Venous Thromboembolism
EF 2009-10
Résumé
There are several genes that are known to increase the risk of blood clots in the veins. After a first blood clot it is not clear if these genetic differences make a carrier more susceptible to having another blood clot (recurrence). It is likely that there is a complex interaction between more than one gene and it is the combination of genes that influences the risk of recurrence. In a previous study called REVERSE we followed over 600 patients with a first blood clot and observed who had a second blood clot. We plan to analyze banked DNA samples from the REVERSE study to examine the interaction of multiple genes in those patients that had a recurrence and those that did not with the objective of better understanding which combinations of genes increase the risk of recurrent blood clots. This knowledge will assist physicians in making decisions about the length of treatment with blood thinners to reduce the risk of recurrence.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Other
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
190075
Name
Rodger Marc A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Cardiovascular System - D
Projecttitle
GENErVTE: Gene Gene Interactions and Recurrent Venous Thromboembolism
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$46,243
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Gene-Gene Interaction; High Risk; Recurrent Venous Thromboembolism (Vte); Single Nucleotide Polymorphisms; Thrombophilia; Unprovoked Venous Thromboembolism
Abstract
There are several genes that are known to increase the risk of blood clots in the veins. After a first blood clot it is not clear if these genetic differences make a carrier more susceptible to having another blood clot (recurrence). It is likely that there is a complex interaction between more than one gene and it is the combination of genes that influences the risk of recurrence. In a previous study called REVERSE we followed over 600 patients with a first blood clot and observed who had a second blood clot. We plan to analyze banked DNA samples from the REVERSE study to examine the interaction of multiple genes in those patients that had a recurrence and those that did not with the objective of better understanding which combinations of genes increase the risk of recurrent blood clots. This knowledge will assist physicians in making decisions about the length of treatment with blood thinners to reduce the risk of recurrence.
Competitiondate
200909
Approvedterm2
1 yr 0 mth
Pinamesdelim
Rodger, Marc A
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $46,243~ $0~
