Grant: Team Grant: Childhood Cancer - Late Effects of Treatment -LOI

Recent medical advances in early cancer detection and effective anti-cancer therapies, including chemotherapy, have significantly increased the survival rates of many childhood cancers in the past decade. Unfortunately, infertility is a common late effect that is apparent in this growing population of childhood cancer survivors only in adulthood. In this research program, our team of expert clinical and basic scientists propose to: 1) develop a method of fertility restoration using stem cells of sperm in boys that can be safely taken; 2) explore the possibility of enriching sperm with good genetic materials from survivors of childhood cancers; and 3) perform a clinical comparative study to evaluate if this sperm enrichment method will result in improved reproductive success in male survivors of childhood cancers seeking fertility treatment.