Grant: Operating Grant
University of Alberta
$100,000.00
Regulation of the p53 Tumor Suppressor in Tumorigenesis.
EF 2015-16
Résumé
The importance of p53 in the prevention of cancer is highlighted by the fact that p53 is inactivated in more than 50 % of all human tumors. Regulation of p53 expression and stability is essential for maintaining normal cell growth. The research team of Dr. Leng is interested in understanding how molecules promote or inhibit the growth of tumors. Dr. Leng is particularly interested six molecules called UBE4B, MDM2, Pirh2, CHIP, Cop1 and p53, which appear to regulate the growth of tumors. They propose to study the mechanism of p53 regulation in tumors. They are using the cutting-edge molecular tools to study the mechanisms of how these E3 ligases regulate p53. Thus, the outcome of this proposal has significant implications and the possible effect in cancer therapy. Successful completion of the proposed experiments could lead to novel anti-cancer therapies that could potentially improve the prognosis for cancer patients and reduce the public health burden from cancer.
Programme
Operating Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
333452
Name
Leng Roger P
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Regulation of the p53 Tumor Suppressor in Tumorigenesis.
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cancer Biology; Oncogenes; Phosphorylation; Protein Degradation; Protein Expression; Tumor Suppressor; Ubiquitin E3 Ligases; Ubiquitination
Abstract
The importance of p53 in the prevention of cancer is highlighted by the fact that p53 is inactivated in more than 50 % of all human tumors. Regulation of p53 expression and stability is essential for maintaining normal cell growth. The research team of Dr. Leng is interested in understanding how molecules promote or inhibit the growth of tumors. Dr. Leng is particularly interested six molecules called UBE4B, MDM2, Pirh2, CHIP, Cop1 and p53, which appear to regulate the growth of tumors. They propose to study the mechanism of p53 regulation in tumors. They are using the cutting-edge molecular tools to study the mechanisms of how these E3 ligases regulate p53. Thus, the outcome of this proposal has significant implications and the possible effect in cancer therapy. Successful completion of the proposed experiments could lead to novel anti-cancer therapies that could potentially improve the prognosis for cancer patients and reduce the public health burden from cancer.
Competitiondate
201505
Approvedterm2
1 yr 0 mth
Pinamesdelim
Leng, Roger P
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
