Grant: Canada Research Chairs
Institut national de la recherche scientifique
$100,000.00
Canada Research Chair in Male Reproductive Toxicology
EF 2024-25
Résumé
Environmental pollutants can exert a negative impact on wildlife reproduction. Male reproductive function appears to be particularly sensitive to pollutants, and in particular those that act as endocrine disruptor. Cellular barriers of the testis and epididymis create a specific environment in the lumen of these organs to enable spermatozoa to be formed, acquire motility and the ability to fertilize. This research Chair in Male Reproductive Toxicology will examine how the epididymis can maintain its barrier following chemical insult and the process by which the epithelium of this tissue can regenerate following chemical-induced cellular damage.
Programme
Canada Research Chairs
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
CRC-2017-00067
Name nom
Cyr, Daniel
Department département
Centre Institut Armand-Frappier - INRS
Organization id
56
Institution établissement
Institut national de la recherche scientifique
Province en
Québec
Province fr
Québec
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2024
Competition year année de concours
2017
Award amount
100000
Program id
CRC
Program name en
Canada Research Chairs
Program name fr
Chaires de recherche du Canada
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
9998
Committee name en
Canada Research Chair Selection Committee
Committee name fr
Comité de sélection des Chaires de recherche du Canada
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
9999
Research subject group en
Not available
Research subject group fr
Non disponible
Research subject en
Not available
Research subject fr
Non disponible
Field of research list codes
RDF10602
Field of research list names en
Cell biology
Field of research list names fr
Biologie cellulaire
Socioeconomic objective list names en
Not available
Socioeconomic objective list names fr
Non disponible
Application title
Canada Research Chair in Male Reproductive Toxicology
Keywords
Male; Epididymis; Tight Junctions; Basal cells; Tissue Regeneration; Blood-epididymis barrier; Claudins; Nonylphenol; Androgens; Cell lines; Transgenic Mice;
Application summary
Environmental pollutants can exert a negative impact on wildlife reproduction. Male reproductive function appears to be particularly sensitive to pollutants, and in particular those that act as endocrine disruptor. Cellular barriers of the testis and epididymis create a specific environment in the lumen of these organs to enable spermatozoa to be formed, acquire motility and the ability to fertilize. This research Chair in Male Reproductive Toxicology will examine how the epididymis can maintain its barrier following chemical insult and the process by which the epithelium of this tissue can regenerate following chemical-induced cellular damage.
