Grant: Project Grant
University of Calgary
$956,250.00
The role of CHD6 chromatin remodelling in cell growth and DNA repair during oxidative stress
EF 2016-17
Résumé
The goal of this project is to determine how an enzyme called CHD6 helps cells that are experiencing stress from oxygen, radiation and/or inflammation to repair DNA, grow and survive. We have discovered that CHD6, which is amplified in many cancers, is an important DNA repair enzyme. In this project, our main goals are (i) to advance biomedical knowledge by determining how CHD6 responds to DNA damage, as well as the significance of this to DNA repair and cancer cell growth; and (ii) to advance future health outcomes by establishing if CHD6 status correlates with colorectal cancer patient outcome with a view towards future therapeutic intervention.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
357183
Name
Goodarzi Aaron
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
The role of CHD6 chromatin remodelling in cell growth and DNA repair during oxidative stress
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$956,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cell Cycle Checkpoint; Chd6; Chromatin Remodelling; Dna Damage; Dna Strand Break; Ionizing Radiation; Microscopy; Molecular Biology; Oxidative Stress; Parp
Abstract
The goal of this project is to determine how an enzyme called CHD6 helps cells that are experiencing stress from oxygen, radiation and/or inflammation to repair DNA, grow and survive. We have discovered that CHD6, which is amplified in many cancers, is an important DNA repair enzyme. In this project, our main goals are (i) to advance biomedical knowledge by determining how CHD6 responds to DNA damage, as well as the significance of this to DNA repair and cancer cell growth; and (ii) to advance future health outcomes by establishing if CHD6 status correlates with colorectal cancer patient outcome with a view towards future therapeutic intervention.
Competitiondate
201610
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Goodarzi, Aaron
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $956,250~ $0~
