Grant: Operating Grant
Université de Montréal
$723,026.00
Roles of cardiotrophin-like cytokine partners in the immune response
EF 2012-13
Résumé
The phenotypes of patients deficient for the gene coding for cardiotrophin-like cytokine (CLC) indicate that this protein has multiple roles in the nervous and immune systems, suggesting that it interacts with multiple partners. We identified two of these partners that could have key roles in autoimmune and Alzheimer diseases. We will investigate the immunoregulatory roles of CLC complexed with these molecules and their functions in models of multiple sclerosis and Alzheimer diseases.
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
281243
Name
Gauchat Jean-François M
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
Roles of cardiotrophin-like cytokine partners in the immune response
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$723,026
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Apolipoprotein E; B Cells; Cytokine Receptors; Cytokines; Eae; Leptin; T Cells
Abstract
The phenotypes of patients deficient for the gene coding for cardiotrophin-like cytokine (CLC) indicate that this protein has multiple roles in the nervous and immune systems, suggesting that it interacts with multiple partners. We identified two of these partners that could have key roles in autoimmune and Alzheimer diseases. We will investigate the immunoregulatory roles of CLC complexed with these molecules and their functions in models of multiple sclerosis and Alzheimer diseases.
Competitiondate
201303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Gauchat, Jean-François M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $723,026~ $0~
