Grant: Project Grant
University of Alberta
$1,105,426.00
The "Ins" and "Outs" of ventilation during sleep: empowering active expiration to counteract loss of inspiratory activity in sleep disordered breathing
EF 2025-26
Résumé
Sleep is a critical period in which breathing is most fragile due to changes in the activity of the neural network that controls breathing. During sleep frequent episodes of respiratory pauses occur and blood oxygen levels drop. If these respiratory disorders are left untreated, serious cardiometabolic complications arise. We are interested in exploring how manipulation of brainstem structures that control respiratory muscle activity during expiration may potentiate ventilation in order to improve breathing in conditions of sleep related respiratory disturbances.
With state of the art technologies we will investigate the cellular mechanisms that control the generation of active expiration and we will demonstrate that potentiation of active expiration improves breathing stability, increases ventilation and reduces sleep disordered breathing.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
564567
Name
Pagliardini Silvia
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
The "Ins" and "Outs" of ventilation during sleep: empowering active expiration to counteract loss of inspiratory activity in sleep disordered breathing
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$1,105,426
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Abdominal Muscles; Active Expiration; Chemogenetics; Emg And Eeg Activity; Hypoxia; Optogenetics; Rats; Sleep Disordered Breathing; Transgenic Mice; Ventilatory Control
Abstract
Sleep is a critical period in which breathing is most fragile due to changes in the activity of the neural network that controls breathing. During sleep frequent episodes of respiratory pauses occur and blood oxygen levels drop. If these respiratory disorders are left untreated, serious cardiometabolic complications arise. We are interested in exploring how manipulation of brainstem structures that control respiratory muscle activity during expiration may potentiate ventilation in order to improve breathing in conditions of sleep related respiratory disturbances.
With state of the art technologies we will investigate the cellular mechanisms that control the generation of active expiration and we will demonstrate that potentiation of active expiration improves breathing stability, increases ventilation and reduces sleep disordered breathing.
Competitiondate
202603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Pagliardini, Silvia
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,105,426~ $0~
