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Grant: Project Grant

Research Institute of the McGill University Health Centre

$1,507,050.00

Unraveling immune-microbiome networks in radiation-based organ-preserving therapies for muscle-invasive bladder cancer

EF 2024-25

Résumé
In our research, we are exploring the connection between the bacteria living in our gut and the immune cells in our bodies, specifically in the context of treating muscle-invasive bladder cancer (MIBC) without removing the bladder. This type of cancer can significantly affect a person's life and survival. Our goal is to unravel the metabolic interactions between immune cells called T cells and the bacteria in the gut during organ-preserving therapies for MIBC. By studying this relationship, we aim to develop better treatment strategies that could improve the quality of life for people with bladder cancer and potentially impact how doctors manage this disease. In simpler terms, we are investigating how the gut's bacteria and our immune system work together to fight bladder cancer, which could lead to more effective and less invasive treatments for patients.
Programme
Project Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database

Tel que publié

Id
509485
Name
Kassouf Wassim
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics 2
Projecttitle
Unraveling immune-microbiome networks in radiation-based organ-preserving therapies for muscle-invasive bladder cancer
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$1,507,050
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bladder Cancer; Immunology; Microbiome; Radiation
Abstract
In our research, we are exploring the connection between the bacteria living in our gut and the immune cells in our bodies, specifically in the context of treating muscle-invasive bladder cancer (MIBC) without removing the bladder. This type of cancer can significantly affect a person's life and survival. Our goal is to unravel the metabolic interactions between immune cells called T cells and the bacteria in the gut during organ-preserving therapies for MIBC. By studying this relationship, we aim to develop better treatment strategies that could improve the quality of life for people with bladder cancer and potentially impact how doctors manage this disease. In simpler terms, we are investigating how the gut's bacteria and our immune system work together to fight bladder cancer, which could lead to more effective and less invasive treatments for patients.
Competitiondate
202409
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Kassouf, Wassim
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,507,050~ $0~