Grant: Master's Award: Canada Graduate Scholarships

Survivors of adolescent and young adult (AYA) cancer, aged 15-39 years, may experience a higher risk of adverse pregnancy outcomes. Although some studies have been conducted on this subject, none have been conducted in Ontario, and the results are not always consistent. Survivors of AYA cancer want more information about the potential risk of adverse pregnancy outcomes. We will conduct a population-based cohort study linking health administrative datasets through ICES Ontario (www.ices.on.ca) to evaluate the risk of adverse pregnancy outcomes in survivors of AYA cancer. We will identify AYAs diagnosed with breast, hematological, and thyroid cancer, as well as melanoma (most common non-gynecological cancers in the AYA population) from 1995 to 2015 from the Ontario Cancer Registry (OCR). Pregnancy outcomes will be identified through The Linked Delivery Mother and Newborn (MOMBABY) dataset, containing birth-related data regarding both mother and baby at delivery. The outcomes of interest will be preeclampsia, placenta previa, placenta accreta, preterm birth, LBW, IUGR, CS, and congenital anomalies. Cancer treatment and time since diagnosis will also be considered in the analysis. We aim to identify factors associated with adverse pregnancy outcomes in female AYA cancer survivors versus no-cancer women. These findings will inform patients and obstetrical care plans for female survivors of AYA cancer.