Grant: Travel Awards - Institute Community Support
Ottawa Hospital Research Institute
$1,000.00
The chemerin effect on granulosa cell transcriptome study showed its role in the expression of three molecules associated with PCOS, the adrenergic receptor alpha 1, propiomelanocortin and adiponectin in rat.
EF 2014-15
Résumé
Polycystic Ovarian Syndrome (PCOS) affects 10 % of women in reproductive age and accounts for 75% of women who are unable to ovulate. It is associated with obesity, cardiovascular diseases and diabetes. In the ovary, it is associated with suppressed growth of the functional unit of the ovary (follicle) and androgen excess. The pathological basis of PCOS is complex, and genetic and environment factors appear to be involved. In the present application we have adopted a animal PCOS model to investigate the pathophysiology of PCOS by studying the potential impact of chemerin on the growth, development and function of the egg (oocyte), and determining if small regulatory RNAs (miRNAs) play a role in the mechanism of regulation in PCOS. My proposed studies will increase the current understanding of the pathophysiology of PCOS and facilitate the development of new treatment strategies for this complex syndrome.
Programme
Travel Awards - Institute Community Support
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Other
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
324534
Name
Nivet Anne-Laure
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Institute of Human Development, Child and Youth Health
Projecttitle
The chemerin effect on granulosa cell transcriptome study showed its role in the expression of three molecules associated with PCOS, the adrenergic receptor alpha 1, propiomelanocortin and adiponectin in rat.
Programtype2
Undefined
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Chemerin; In Vitro Granulosa Primary Cell Culture; In Vivo Dht Treated Rat Pcos Model; Microarrays; Polycystic Ovarian Syndrome; Protein Assay; Qpcr
Abstract
Polycystic Ovarian Syndrome (PCOS) affects 10 % of women in reproductive age and accounts for 75% of women who are unable to ovulate. It is associated with obesity, cardiovascular diseases and diabetes. In the ovary, it is associated with suppressed growth of the functional unit of the ovary (follicle) and androgen excess. The pathological basis of PCOS is complex, and genetic and environment factors appear to be involved. In the present application we have adopted a animal PCOS model to investigate the pathophysiology of PCOS by studying the potential impact of chemerin on the growth, development and function of the egg (oocyte), and determining if small regulatory RNAs (miRNAs) play a role in the mechanism of regulation in PCOS. My proposed studies will increase the current understanding of the pathophysiology of PCOS and facilitate the development of new treatment strategies for this complex syndrome.
Competitiondate
201501
Approvedterm2
1 yr 0 mth
Pinamesdelim
Nivet, Anne-Laure
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Human Dev &Child &Yth~ $1,000~ $0~
