Grant: Discovery Grants Program - Individual
University of Western Ontario
$35,000.00
Regulation of membrane trafficking by the PACS family of proteins
EF 2014-15
Résumé
The correct movement of proteins in the various cellular compartments is vital to the proper function of a cell. We study a family of proteins called the Phosphofurin Acidic Cluster Sorting Proteins (PACS-1 and 2) that specifically interact with numerous client proteins and traffic them to precise cellular locations to regulate specific cellular functions such as the regulation of cell death. It remains unknown how PACS can interact with numerous cellular partners and exert different affects. Our work will aim to decipher specific domains on the PACS proteins and on their client proteins that enable these interactions. Furthermore, we will study specific signals located in the PACS proteins enabling their localization to different cellular compartments. Together, these studies will advance our knowledge of basic fundamental principles ensuring the proper localization of protein to various cellular compartments.
Programme
Discovery Grants Program - Individual
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
435677-2013
Name nom
Dikeakos, DimitriosJimmy
Department département
Microbiology and Immunology
Organization id
36
Institution établissement
University of Western Ontario
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2014
Competition year année de concours
2013
Award amount
35000
Program id
RGPIN
Program name en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
1501
Committee name en
Genes, Cells and Molecules
Committee name fr
Gènes, cellules et molécules
Area of application code
1201
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Life sciences (including biotechnology)
Area of application fr
Sciences de la vie (y compris biotechnologie)
Research subject code
5100
Research subject group en
Cell biology
Research subject group fr
Biologie cellulaire
Research subject en
Cell biology
Research subject fr
Biologie cellulaire
Partie
2
Nb partie
5
Application title
Regulation of membrane trafficking by the PACS family of proteins
Keyword
NSERC
Application summary
The correct movement of proteins in the various cellular compartments is vital to the proper function of a cell. We study a family of proteins called the Phosphofurin Acidic Cluster Sorting Proteins (PACS-1 and 2) that specifically interact with numerous client proteins and traffic them to precise cellular locations to regulate specific cellular functions such as the regulation of cell death. It remains unknown how PACS can interact with numerous cellular partners and exert different affects. Our work will aim to decipher specific domains on the PACS proteins and on their client proteins that enable these interactions. Furthermore, we will study specific signals located in the PACS proteins enabling their localization to different cellular compartments. Together, these studies will advance our knowledge of basic fundamental principles ensuring the proper localization of protein to various cellular compartments.
