Grant: Operating Grant

MEF2 is a protein molecule in the heart and skeletal muscle that serves to orchestrate the control of many genes. In this regard, MEF2 serves as a communication hub between signals from outside the cell and the control of gene expression within the cell nucleus. Thus, MEF2 sits at a pivotal point in regulating key aspects of heart and skeletal muscle cell function. We are trying to understand the nature of these processes and also learn how to modulate them pharmacologically so that some control over cardiac gene expression can be exerted in pathological circumstances such as heart failure.