Grant: Project Grant

Type 2 diabetes is a common health problem, affecting more than 20% of people in Canada and millions worldwide. It's especially worrisome because it can lead to serious heart conditions, which are often the main cause of death in those with diabetes. Unfortunately, we don't fully understand why diabetes affects people differently or how it leads to heart disease. The DECIDE-CCVS project is tackling this issue. Its goals are to: 1) Identify groups of people with type 2 diabetes who have different heart health outcomes and who respond differently to a specific diabetes medication (called sodium-glucose cotransporter- 2 inhibitor). The project will look at data from over 54,000 patients from six large international studies. 2) Understand the biological mechanisms of these groups by examining a wide range of biological data, including protein levels, metabolites, fats in the body, heart imaging, blood vessel health, and social and demographic information. The ultimate aim is to create personalized treatments for diabetes and its related heart issues. By using detailed data from past studies and patient information, the DECIDE-CCVS project is set to make a big impact on how we treat diabetes and prevent heart complications. This research is at the cutting edge of diabetes, metabolism, and nutrition studies because it seeks to explain the underlying biological changes in diabetes that lead to different heart health outcomes.